Intraorally rapidly desintegrable tablet

Details Intraorally rapidly desintegrable tablet Intraorally rapidly desintegrable tablet

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/00 (2006.01) A61K 31/164 (2006.01) A61K 45/00 (2006.01) A61K 47/10 (2006.01) A61K 47/26 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2439873

Tablets quickly disintegrating in the oral cavity without resort of water and sustaining a practically usable tablet hardness which contain: (a) a pharmacologically active ingredient having a solubility in water of at least about 1 mg/ml; (b) crystals or fine particles of D-mannitol having an average particle diameter of primary particles of about 30 m or more and a specific surface area of about 0.4 m2/g or less; and (c) crospovidone.

La présente invention concerne des comprimés se délitant rapidement dans la bouche sans consommation d'eau, tout en conservant la forme dure du comprimé pratiquement utilisable. Un tel comprimé contient (a) une substance pharmacologiquement active d'une solubilité dans l'eau d'au moins 1 mg/ml. Le comprimé contient également, d'une part (b) des cristaux ou de fines particules de D-mannitol d'un diamètre particulaire moyen pour les particules primaires d'au moins environ 30 ?m et d'une superficie spécifique n'excédant pas environ 0,4 m /g, et d'autre part (c) du crospovidone.

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