Intrathecal administration of rituximab for treatment of...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 51/10 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2405632

This invention describes methods of using anti-B cell antibodies, preferably anti-CD20 antibodies, and most preferably Rituximab, to treat B cell lymphomas of the brain, especially primary central nervous system lymphomas (PCNSLs), and to prevent meningeal relapse. The antibodies can be administered intrathecally alone, or in combination with other chemotherapeutics, such as methotrexate, or other anti-B cell antibodies to treat PCNSL in both immunocompromised and non-immunocompromised patients. These antibodies can also be used to diagnose patients with CNS lymphoma, especially in immunocompromised patients.

Cette invention concerne des procédés pour utiliser des anticorps anti-B, de préférence des anticorps anti-CD20, et idéalement le Rituximab, pour traiter des lymphomes de cellules B du cerveau, spécialement des lymphomes primaires du système nerveux central, et pour prévenir une rechute au niveau des méninges. Les anticorps peuvent être administrés seuls de manière intrathécale, ou en combinaison avec d'autres médicaments chimiothérapeutiques, tels que le méthotrexate, ou d'autres anticorps anti-B pour traiter les lymphomes primaires du sytème nerveux central chez les patients immunodéprimés comme chez les patients non immunodéprimés. Ces anticorps peuvent également être utilisés pour diagnostiquer chez des patients un lymphome du système nerveux central, spécialement chez les patient immunodéprimés.

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