Intrauterine chemical necrosing method, composition, and...

A - Human Necessities – 61 – K

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A61K 33/38 (2006.01) A61K 47/36 (2006.01) A61M 31/00 (2006.01) A61P 15/00 (2006.01)

Patent

CA 2289462

A method and composition for effecting chemical necrosis of a tissue lining of a mammalian body cavity, particularly a uterine endometrium, by delivering a caustic tissue necrosing composition, e.g., a silver nitrate and dextran paste, to the tissue to be necrosed and allowing the paste to remain in contact with the target tissue for a period of time sufficient to chemically necrose substantially the entirety of the tissue lining, and then contacting the caustic composition with a deactivating agent, e.g., an aqueous sodium chloride solution, thereby rendering the caustic composition non-caustic, and then rinsing the cavity. Compositions and methods for delivering medicaments are also disclosed.

L'invention concerne une méthode et une composition qui permettent de nécroser chimiquement le revêtement tissulaire d'une cavité corporelle d'un mammifère, notamment l'endomètre utérin. Selon la méthode, on administre au tissu à nécroser une composition nécrosante caustique pour les tissus, telle qu'une pâte à base de nitrate d'argent et de dextrane, et on laisse ladite pâte en contact avec le tissu cible pendant une durée suffisante pour nécroser chimiquement sensiblement la totalité du revêtement tissulaire; puis on met en contact la composition caustique avec un agent de désactivation, tel qu'une solution aqueuse de chlorure de sodium, ce qui rend la composition non caustique, et on rince la cavité. L'invention concerne également des compositions et des méthodes qui permettent d'administrer des médicaments.

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