A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/00 (2006.01) A61K 31/4196 (2006.01) A61K 31/5685 (2006.01)
Patent
CA 2459434
The invention relates to a method for the treatment of an oestrogen-dependent proliferative disorder of the uterus such as endometriosis and uterine fibroids in a patient, by administering an aromatase inhibitor to the patient intravaginally. This achieves high local levels of aromatase inhibitor Locally, and therefore avoids some of the adverse reactions that are observed when aromatase inhibitors are delivered orally. Further, intravaginal delivery allows inhibition of the local lesional production without significantly affecting the circulating levels which have been produced by the ovaries. This results in minimal side-effects and will allow for longer term treatment than current therapies.
Cette invention concerne une méthode de traitement d'une maladie de l'utérus dépendante des oestrogènes à évolution chronique, telle que l'endométriose et les fibromes utérins, chez une patiente, ledit traitement s'effectuant par administration intravaginale d'un inhibiteur de l'aromatase. Cette méthode permet d'obtenir, localement, des niveaux élevés d'inhibition de l'aromatase, et donc d'éviter quelques-uns des effets indésirables observés lorsque des inhibiteurs de l'aromatase sont administrés par voie orale. De plus, l'administration intravaginale inhibe l'apparition de lésions locales sans affecter de manière significative les niveaux de circulation produits par les ovaires. La méthode de l'invention induit des effets secondaires minimaux et offre un traitement à plus long terme que les thérapies courantes.
Knox Peter
Pappa Helen
Ares Trading Sa
Kirby Eades Gale Baker
Metris Therapeutics Limited
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