A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7056 (2006.01) A61K 9/02 (2006.01) A61P 15/02 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2378572
A highly storage-stable composition for vaginal administration of clindamycin is disclosed which is useful for the treatment of bacterial vaginosis. The composition is a vaginal suppository containing an antimicrobially effective amount of clindamycin dispersed in a Hard Fat NF suppository base. Hard Fat NF suppository bases provide a clindamycin product having long term storage stability while providing efficacy against bacterial vaginosis which is equivalent to clindamycin vaginal creams.
L'invention concerne une composition stable à capacité de stockage à long terme pour l'administration vaginale de clindamycine, afin de traiter la vaginose bactérienne. Cette composition se présente sous forme de suppositoire vaginal contenant une quantité efficace antimicrobienne de clindamycine, dispersée dans une base de suppositoire <= Gras Dur (mélange de glycérides et d'acides gras selon le National Formulary). La base de ce suppositoire "Gras Dur" permet au produit à base de clindamycine d'acquérir une stabilité de stockage à long terme, tout en étant aussi efficace que les crèmes vaginales, pour lutter contre la vaginose bactérienne.
Bowman Phil B.
Chao Robert S.
Pena Lorraine E.
Pesheck Carolyn V.
Macrae & Co.
Pharmacia & Upjohn Company
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