Intravaginal delivery of biologically active polypeptides

A - Human Necessities – 61 – K

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A61K 47/00 (2006.01) A61K 9/00 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/20 (2006.01) A61K 47/42 (2006.01)

Patent

CA 1336676

Pharmaceutical compositions of matter adapted for intravaginal administration comprise a biologically active polypeptide, an absorption promoter, such as an anionic and/or nonionic surfactant or a nonionic surfactant and an aliphatic carboxylic acid, optionally an animal and/or vegetable protein and a nontoxic pharmaceutically acceptable carrier or diluent therefor, in a formulation suitable for intravaginal administra- tion. Preferred compositions comprise calcitonin as the biologically active polypeptide. Preferred absorption promoters are anionic surfactants, e.g., sodium lauryl sulfate, and the combination absorp- tion promoter of a nonionic surfactant and a medium chain aliphatic carboxylic acid or its salt, e.g. polyoxyethylenealkylphenylether and a medium chain aliphatic carboxylic acid.

593354

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