Intravaginal drug delivery devices for the administration of...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/568 (2006.01) A61K 9/00 (2006.01) A61P 5/26 (2006.01)

Patent

CA 2288046

The invention relates to an intravaginal shell or core drug delivery device suitable for administration to the human or animal female. The device comprises testosterone or a testosterone precursor in a polymer matrix, surrounded by a sheath, and is capable of releasing the testosterone or testosterone precursor in a substantially zero order pattern on a daily basis for at least three weeks. The device is intended to restore circulating testosterone levels to normal physiological range or to induce supratherapeutic testosterone levels.

L'invention concerne un dispositif servant à administrer par voie intravaginale un médicament sous forme de noyau ou d'ovule à la femme ou à la femelle animale. Ce dispositif est composé de testostérone ou d'un précurseur de testostérone dans une matrice polymère entourée par une gaine et est capable de libérer le testostérone ou le précurseur de testostérone de façon soutenue sur une base journalière d'au moins trois semaines. Ce dispositif est conçu pour remettre les niveaux de testostérone en circulation dans une plage physiologique normale ou pour provoquer des niveaux de testostérone suprathérapeutiques.

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