Intravaginal rings with insertable drug-containing core

Details Intravaginal rings with insertable drug-containing core Intravaginal rings with insertable drug-containing core

A - Human Necessities

61

F

A61F 6/06 (2006.01) A61F 6/08 (2006.01) A61K 9/00 (2006.01) A61K 31/56 (2006.01) A61K 47/30 (2006.01) A61M 31/00 (2006.01)

Patent

CA 2232635

Disclosed is a vaginal ring containing a ring body made of a first polymeric material having at least one hollow internal channel defining an opening to the exterior of said body and which channel is adapted to receive a drug-containing core through said opening, and a core containing at least one intravaginally administrable drug dispersed in a second polymeric material disposed in the channel. The core is positioned in the vaginal ring body suitably prior to use in order to substantially avoid initial bursts of drug into the tissues of the subject and resultant side effects such as nausea and vomiting. Representative drugs include contraceptive agents and other steroidal substances for use in hormone replacement therapy. Also disclosed are methods for preparing the vaginal rings, kits for assembling the vaginal rings, and methods of using the vaginal rings to achieve intravaginal delivery of drugs to a female.

Anneau vaginal comprenant un corps d'anneau fabriqué d'un premier polymère muni d'au moins un conduit interne creux définissant une ouverture à l'extérieur du corps et adapté à recevoir par cette ouverture un noyau contenant un médicament, ainsi qu'un noyau contenant au moins un médicament, qui peut être administré par le vagin, dispersé dans un deuxième polymère placé dans le conduit. Ce noyau est placé dans le corps de l'anneau vaginal bien avant l'utilisation de façon à éviter des jets initiaux de médicament dans les tissus du sujet, qui peuvent provoquer des effets secondaires tels que nausée et vomissement. Des médicaments typiques comprennent des agents contraceptifs et d'autres substances stéroïdes utilisées dans l'hormonothérapie substitutive. L'invention présente aussi des méthodes pour préparer les anneaux vaginaux, des trousses pour les assembler et des méthodes d'utilisation pour l'administration vaginale de médicaments.

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