Intravaginal treatment of vaginal infections with buffered...

A - Human Necessities – 61 – K

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167/239

A61K 31/415 (2006.01) A61K 9/00 (2006.01)

Patent

CA 1337279

A composition and method for treatment of bacterial vaginosis and/or trichomoniasis are disclosed. An afflicted vagina is treated with a therapeutically effective amount of a buffered metronidazole composition having a pH in the range of about 3 to about 4.25, preferably about 3.75 to about 4.25. A preferred such composition comprises metronidazole, a gelled hydrophobic and water-dispersible polymer, such as a polyacrylic acid polymer having a molecular weight in the range of about 1,250,000 to about 4,000,000 daltons, and an aqueous solvent for the metronidazole.

613846

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