Intravascular blood conditioning device and use thereof

Details Intravascular blood conditioning device and use thereof Intravascular blood conditioning device and use thereof

A - Human Necessities

61

F

A61F 2/01 (2006.01) A61M 1/16 (2006.01) A61M 1/36 (2006.01)

Patent

CA 2430554

Disclosed is an implantable, intravascular device for treating a medical disorder associated with the presence of a particular molecule in the systemic circulation of a mammal. When implanted, the device removes or reduces the concentration of the molecule in the blood stream thereby conditioning the blood. The device includes an anchor (10) component immobilizable to an inner wall of an intact blood vessel (30) and a cartridge (20) component that is retained in place within the blood vessel by the immobilized anchor. the cartridge contains a converting agent, for example, viable cells or enzyme preparations, that catabolize or convert the molecule of interest into one or more other molecules that are not associated with the disorder. The invention also provides a minimally or non-invasive method for introducing into and, optionally, removing from the blood vessel the device of the invention.

L'invention concerne un dispositif implantable, intravasculaire, permettant de traiter un trouble médical associé à la présence d'une molécule particulière dans la circulation systémique d'un mammifère. Lorsqu'il est implanté, ce dispositif supprime cette molécule ou abaisse sa concentration dans la circulation sanguine, et traite ainsi le sang. Ce dispositif comprend un élément d'ancrage (10) qui peut être immobilisé sur la paroi interne d'un vaisseau (30) sanguin intact et un élément cartouche (20) qui est maintenu en place dans le vaisseau sanguin par l'ancrage immobilisé. La cartouche contient un agent de conversion, par exemple des cellules viables ou des préparations enzymatiques, qui catabolisent ou convertissent la molécule cible en une ou plusieurs autres molécules qui ne sont pas associées au trouble. Cette invention concerne en outre un procédé non effractif ou à effraction minimale permettant d'introduire ce dispositif dans un vaisseau sanguin, et éventuellement de le retirer du vaisseau sanguin.

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