A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/153
A61K 47/00 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 41/00 (2006.01) A61K 49/18 (2006.01)
Patent
CA 1109792
ABSTRACT OF THE DISCLOSURE The intravascularly-administrable, magnetically-local- izable biodegradable carrier comprises microspheres formed from an amino acid polymer matrix with magnetic particles embedded therein. The microspheres can be used for intra-arterial admin- istration and capillary level localization and/or release of therapeutic and diagnostic agents, thereby obtaining much more precise targeting of the agents than has heretofore been possible. Also a process is provided for incorporating water-sol uble therapeutic agents in albumin microspheres. This process is particularly advantageous where the therapeutic agent is heat- sensitive. All steps of the process can be carried out at rela- tively low temperatures, such as ambient room temperature. The process may be applied to the preparation or the above mentioned intravascularly-administrable, magnetically-responsive micro- spheres.
308471
Senyei Andrew E.
Widder Kenneth J.
Gowling Lafleur Henderson Llp
Northwestern University
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