A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/711 (2006.01) A61K 31/713 (2006.01) A61M 5/00 (2006.01) C12M 3/00 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2527303
An intravenous delivery method is described that enables delivery of polynucleotides to extravascular cells of a mammalian limb. The method involves the injection of polynucleotides into a distal vein of a limb that is transiently occluded. Polynucleotide delivery is facilitated by rapid injection in sufficient volume to enable extravasation of the solution into surrounding tissue.
L'invention concerne un procédé d'administration intraveineuse qui permet d'administrer des polynucléotides à des cellules extravasculaires d'un membre d'un mammifère. Le procédé consiste notamment à injecter des polynucléotides dans une veine distale d'un membre provisoirement occlus. L'administration de polynucléotides est facilitée par l'injection rapide en dose suffisante qui permet l'extravasation de la solution dans les tissus avoisinants.
Hagstrom James E.
Hegge Julia
Herweijer Hans
Goudreau Gage Dubuc
Mirus Bio Corporation
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