A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/51 (2006.01)
Patent
CA 2518223
Provided are poly(lactic-co-glycolic acid) (PLGA) and poly(lactic acid) (PLA) nanoparticles that encapsulate a low~ molecular weight and water-soluble drug and can deliver the drug to target legion sites where the particles gradually release the drug over a prolonged period of time. The nanoparticles are prepared by allowing the low-molecular, water-soluble and non-peptide drug to interact with a metal ion so as to make the drug hydrophobic, encapsulating the hydrophobicized drug into PLGA or PLA nanoparticles, and allowing a surfactant to be adsorbed onto the surface of the particles.
L'invention concerne des nanoparticules d'acide poly(lactique-co-glycolique) (PLGA) et d'acide poly(lactique) (PLA) encapsulant un médicament de faible masse moléculaire et soluble dans l'eau, et pouvant libérer le médicament aux sites de lésions cibles, les particules libérant progressivement le médicament sur une période prolongée. Les nanoparticules sont préparées en permettant l'interaction d'un médicament non peptidique, soluble dans l'eau, de faible masse moléculaire et d'un ion métallique de sorte à rendre ce médicament hydrophobe et à encapsuler ce médicament hydrophobisé en nanoparticules PLGA ou PLA, et à permettre à un surfactant d'être adsorbé à la surface de ces particules.
Ishihara Tsutomu
Mizushima Yutaka
Ltt Bio-Pharma Co. Ltd.
Smart & Biggar
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