A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/139
A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61P 31/04 (2006.01) C07K 1/18 (2006.01) C07K 16/12 (2006.01)
Patent
CA 1341505
Intravenously administered polyclonal immunoglobulin preparation for the treatment and prophylaxis of bacterial infections containing at least 50% by weight of IgM in terms of the total content of immunoglobulin, exhibiting a low anticomplementary activity, being stable in aqueous solution, and being free of viruses. It can also consist of or also contain a mixture of several monoclonal IgM antibodies. The point of departure for its manufacture is an immunoglobulin-containing fraction of human, animal, or bacterial provenance. The fraction is treated with an anion exchanger that is eluted with a saline or pH gradient and the eluate is optionally subjected to gel filtration, treated before or after the chromatography with .beta.-propiolactone and PEG 4000, and optionally heated. Treatment with .beta.-propiolactone and ultraviolet light, treatment with solvents and detergents, or pasteurization can also be conducted. Proteins, sugars, or mixtures of amino acids are optionally added to the preparation.
605869
Dichtelmueller Herbert
Kothe Norbert
Moeller Wolfgang
Piechaczek Detlef
Rudnick Dieter
Biotest Pharma Gmbh
Fetherstonhaugh & Co.
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