Introducing delta 11 unsaturation into steroid compounds

Details Introducing delta 11 unsaturation into steroid compounds Introducing delta 11 unsaturation into steroid compounds

C - Chemistry, Metallurgy

07

J

260/7

C07J 9/00 (2006.01) C07J 31/00 (2006.01)

Patent

CA 1059987

INTRODUCING .DELTA.11 UNSATURATION INTO STEROID COMPOUNDS Abstract of the Disclosure A process for the introduction of .DELTA.11 unsaturation into steroid compounds having a C-12 sulfonate ester group is described. Dehydrosulfonation is carried out by reacting the sulfonate with a hexaalkylphosphoric triamide. The process is particularly useful with steroid compounds that also contain a blocked C-7 hydroxy group. The process yields the 11-enate in preference to the 6,11-dienate. The yield of the process can be increased by carrying out the reaction in the presence of a weak base. -1-

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