Invasive bacteria-based viral vaccines

Details Invasive bacteria-based viral vaccines Invasive bacteria-based viral vaccines

C - Chemistry, Metallurgy

12

N

C12N 15/38 (2006.01) A61K 39/12 (2006.01) A61K 39/21 (2006.01) A61K 39/245 (2006.01) A61K 39/29 (2006.01) A61P 31/18 (2006.01) A61P 31/20 (2006.01) A61P 31/22 (2006.01) C12N 15/87 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2379832

The invention relates to a vaccine against herpes simplex virus (HSV) comprising an invasive but attenuated or non-pathogenic bacterium, which bacterium comprises a coding sequence encoding a HSV antigen in a form that enables said coding sequence to be transferred to a host cell of a human or animal host which the bacterium is capable of invading and to be expressed in said cell to form said antigen without the introduction of an antimicrobial agent to lyse the bacterium. The invention also provides similar vaccines against other viruses.

L'invention concerne un vaccin contre le virus de l'herpès simplex comprenant une bactérie invasive mais atténuée ou non pathogène. Cette bactérie comprend une séquence de codage codant un antigène du virus de l'herpès simplex sous une forme qui permet à ladite séquence de codage d'être transférée à une cellule hôte d'un hôte animal ou humain que la bactérie peut envahir et d'être exprimée dans ladite cellule pour former ledit antigène sans introduction d'un agent antimicrobien pour lyser la bactérie. L'invention concerne également des vaccins semblables contre les autres virus.

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