Inverted chimeric and hybrid oligonucleotides

Details Inverted chimeric and hybrid oligonucleotides Inverted chimeric and hybrid oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2229811

The invention relates to modified oligonucleotides that are useful for studies of gene expression and for the antisense therapeutic approach. The invention provides inverted hybrid oligonucleotides and inverted chimeric oligonucleotides, both of which produce reduced side effects, relative to traditional phosphorothioate, hybrid or chimeric oligonucleotides.

L'invention concerne des oligonucléotides modifiés utiles pour des études de l'expression génique et pour l'approche thérapeutique par antisens. Elle permet de produire des oligonucléotides hybrides inversés et des oligonucléotides chimères inversés ayant peu d'effets secondaires, apparentés aux oligonucléotides hybrides ou chimères traditionnels à base de thiophosphate.

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