Iodinated aroyloxy ketones

Details Iodinated aroyloxy ketones Iodinated aroyloxy ketones

C - Chemistry, Metallurgy

07

C

C07C 233/54 (2006.01) A61K 49/04 (2006.01) C07C 255/17 (2006.01) C07D 213/55 (2006.01) C07D 307/33 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2184912

Compounds having structure (Ia) or (Ib), wherein (Z-)-COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 20; R1, R2, R3 and R4 are inde- pendently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, acylamino, acetami- doalkyl, acetamidoaryl, -COO-alkyl, -COO-aryl, -COO- aralkyl, -CO-alkyl, -CO-aryl, -CO-heterocyclyl, cyano or heterocyclyl; R5 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl, heterocyclyl, or a Z-CO2-CR1R2-(- CR3R4-)-n group, wherein Z, R1, R2, R3, R4 and n are as defined above, m is an integer from 0 to 10, p is an integer from 0 to 10, and m + p 1 are useful as contrast agents in x-ray imaging compositions and methods.

L'invention a pour objet des composés de structure (Ia) ou (Ib), où (Z-)-COO représente un radical d'un acide aromatique iodé; n représente un nombre entier de 0 à 20; R<1>, R<2>, R<3> et R<4> représentent indépendamment l'un de l'autre H, alkyle, fluoroalkyle, cycloalkyle, aryle, aralkyle, alcoxy, aryloxy, halogène, hydroxy, acylamino, acétaminoalkyle, acétamidoaryle, -COO-alkyle, -COO-aryle, -COO-aralkyle, -CO-alkyle, -CO-aryle, -CO-hétérocyclyle, cyano ou hétérocyclyle; R<5> représente H, alkyle, fluoroalkyle, cycloalkyle, aryle, aralkyle, alcoxyalkyle, hétérocyclyle, ou un groupe Z-CO2-CR<1>R<2>-(-CR<3>R<4>-)-n, où Z, R<1>, R<2>, R<3>, R<4> et n sont tels que définis ci-dessus, m représente un nombre entier de 0 à 10, p un nombre entier de 0 à 10, et m + p >/= 1. Lesdits composés sont utilisés comme agents de contraste dans des compositions et des procédés d'imagerie radiographique.

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