Iodinated esters

Details Iodinated esters Iodinated esters

C - Chemistry, Metallurgy

07

C

C07C 233/88 (2006.01) A61K 49/04 (2006.01) C07C 233/54 (2006.01) C07C 237/46 (2006.01) C07D 317/28 (2006.01) C07D 317/36 (2006.01) C07D 319/06 (2006.01) C07D 333/16 (2006.01) C07D 333/32 (2006.01)

Patent

CA 2045543

Water insoluble iodinated esters of formula (I), (see fig. I) in which R1 is a substituted or unsubstituted C1-20 aliphatic, C7-20 araliphatic or C6-20 aryl group or a C1-20 heterocyclic group having one or more hetero atoms selected from O, S and N; R2 is hydrogen or a substituted or unsubstituted C1-6 aliphatic, C6-10 aryl or C7-20 araliphatic group; and R3 is a group as defined above for R1, which may be the same as or different from R1, or R2 and R3 together represent a substituted or unsubstituted C1-4 alkylene group, the molecule containing at least one iodine atom and being metabolisable to products which are soluble in body fluids and are physiologically acceptable. The esters are useful in X-ray and ultrasound imaging, especially liver and spleen imaging.

L'invention concerne des esters iodés insolubles de la formule (I), dans laquelle R1 représente un groupe aliphatique C1-20, araliphatique C7-20 ou aryle C6-20, à substitution ou sans substitution, ou un groupe hétérocyclique C1-20 comportant un ou plusieurs hétéroatomes choisis entre 0,S et N; R2 représente hydrogène ou un groupe aliphatique C1-6, aryle C6-10 ou araliphatique C7-20 à substitution ou sans substitution; et R3 représente un groupe défini tel que ci-dessus pour R1, pouvant être identique ou différent de R1, ou R2 et R3 représentent ensemble un groupe alkylène C1-4 à substitution ou sans substitution, la molécule contenant au moins un atome d'iode et pouvant être métabolisée en produits solubles dans des fluides biologiques et physiologiquement acceptables. Les esters sont utiles en imagerie à rayons X et à ultrasons, notamment l'imagerie du foie et de la rate.

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