Ion channel assay methods

Details Ion channel assay methods Ion channel assay methods

G - Physics

01

N

G01N 33/483 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2413711

A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.

L'invention concerne un procédé de caractérisation de l'activité biologique d'un composé d'intérêt potentiel qui peut inclure l'exposition des cellules au composé d'intérêt potentiel, et ensuite l'exposition des cellules à une application répétitive de champs électriques de manière à régler le potentiel transmembranaire à un niveau correspondant à une tension prédéfinie dépendant de l'état d'un canal ionique cible.

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