A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61K 38/09 (2006.01) A61K 38/10 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01) C07K 14/46 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2180748
An N-terminal substituted peptide or pro- tein having formula (1). X is a biologically ac- tive amphiphilic ion channel-forming peptide or protein. T is a lipophilic moiety, and prefer- ably, T is formula (2), wherein R is a hydro- carbon (alkyl or aromatic or alkylaromatic) having at least 2 and no more than 10 carbon atoms. T is preferably an octanoyl group. W is T or hydrogen. The N-terminal substituted peptides and proteins have improved biological activity against target cells, viruses, and virally-infected cells.
Peptide ou protéine à substitution N-terminale correspondant à la formule (1), dans laquelle X est un peptide ou protéine biologiquement actif formant un canal ionique amphiphilique, T est une fraction lipophile et, de préférence, représente (2) (où R est un hydrocarbure (alkyle ou aromatique ou alkylaromatique) comportant au moins 2 et au maximum 10 atomes de carbone. T est de préférence un groupe octanoyle. W est T ou hydrogène. Ces peptides et protéines à substitution N-terminale présentent une activité biologique améliorée contre des cellules cibles, des virus et des cellules infectées par un virus.
Kari U. Prasad
Mclane Michael
Williams Taffy J.
Magainin Pharmaceuticals Inc.
Smart & Biggar
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