Ion channel modulators

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 213/36 (2006.01) A61K 31/426 (2006.01) A61K 31/435 (2006.01) A61P 9/00 (2006.01) C07D 213/74 (2006.01) C07D 277/42 (2006.01)

Patent

CA 2672236

The present teachings provide compounds of Formula (I) and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R1, R1', R2, R3, R4 R4', and p are defined herein. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.

La présente invention concerne des composés de formule (I) et des sels, hydrates et esters acceptables du point de vue pharmaceutique de ceux-ci, dans laquelle Ar, R1, R1', R2, R3, R4, R4' et p sont tels que définis ici. La présente invention concerne également des procédés servant à produire lesdits composés et leurs sels, hydrates et esters acceptables du point de vue pharmaceutique et des procédés de traitement d'une affection ou d'un trouble pathologique, ou de soulagement d'un symptôme de celui-ci, utilisant lesdits composés y compris leurs sels, hydrates et esters acceptables du point de vue pharmaceutique. Les composés peuvent être utiles pour moduler l'activité de canaux ioniques par exemple pour traiter un grand nombre d'affections associées à la modulation anormale d'un ou plusieurs canaux calciques dépendants d'un potentiel d'action.

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