Ion channels as targets for sleep-related drugs

Details Ion channels as targets for sleep-related drugs Ion channels as targets for sleep-related drugs

A - Human Necessities

01

K

A01K 67/033 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2509528

The invention provides screening methods for isolating short sleep, no rebound and sleep deprivation resistant Drosophila mutants. Such mutants are further useful to facilitate identification of sleep-related molecular targets. The invention also encompasses methods for identifying a sleep or wakefulness- promoting compound based on the compound's ability to modulate two pore domain K+ channels.

L'invention concerne des méthodes de criblage permettant d'isoler des mutants de Drosophila résistants au sommeil insuffisant, au phénomène de rebond et à la privation de sommeil. De tels mutants sont en outre utiles pour faciliter l'identification de cibles moléculaires associées au sommeil. L'invention concerne également des méthodes d'identification d'un composé favorisant le sommeil ou l'état de veille, en fonction de la capacité du composé à moduler deux canaux K+ du domaine poreux.

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