C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/512.8, 260/4
C07C 69/80 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01) A61K 31/19 (2006.01) A61K 31/235 (2006.01) A61K 31/24 (2006.01) A61K 49/04 (2006.01) C07C 55/00 (2006.01) C07C 61/00 (2006.01) C07C 63/08 (2006.01) C07C 63/10 (2006.01) C07C 63/30 (2006.01) C07F 13/00 (2006.01) C07C 63/307 (2006.01) C07C 63/68 (2006.01) C07C 69/76 (2006.01)
Patent
CA 1170268
ABSTRACT OF THE DISCLOSURE Ionic 5-C-substituted 2,4,6-triiodo-isophthalic acid compounds of the general formula I Image (I) in which X represents -CONR1R2, -CH2NH?Acyl or -CH2OH; Y re- presents -NR3R4, -NH?Acyl or -OR5, R1, R2, R3 and R4 can be identical or different, and each is hydrogen, C1-6-alkyl or C2-8-alkyl substituted by 1-5 OH groups and/or by one C1-3- alkoxy group; R5 is C1-6-alkyl or C2-8-alkyl substituted by 1-5 OH groups and/or by one C1-3-alkoxy group; Acyl which can be the same or different in X and Y, is C2-6-alkanoyl or C2-6- alkanoyl substituted by 1-4 OH groups and/or by one C1-3-alkoxy group and physiologically tolerable salts thereof with inorganic and organic bases and a process for the manufacture of these compounds. The compounds of the general formula I and their salts are suitable for use as X-ray contrast agents and owing to their good general tolerability are especially suitable for use in urography and in computer tomography; they may accord- ingly be made up into X-ray contrast preparations with physi- ologically tolerable carriers.
368212
Gries Heinz
Mutzel Wolfgang
Pfeiffer Heinrich
Speck Ulrich
Marks & Clerk
Schering Aktiengesellschaft
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