A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
167/156, 128/60
A61L 15/28 (2006.01) A61L 15/44 (2006.01)
Patent
CA 1322169
ABSTRACT OF THE DISCLOSURE Novel wound or burn dressings are provided herein. Such dressings provide for the systemic administration of a physiologically- or biologically-active agent by controlled release of the agent into such wound. Such dressing includes a substrate, e.g. in the form of a fabric or cloth at least a portion of which is cellulosic, which has ionic exchange sites thereon, e.g. by being chemically-modified to convert hydroxyl groups in such cellulosic portions to ionic-adsorbing sites. An ionic form of such physiologically- or biologically-active agent is absorbed therein, e.g. by ionic bonding. Ionic bonds hold that agent temporarily to the substrate for controlled release therefrom in proportion to the amount of exudate in contact with the substrate. The ionic bonds are formed by adsorbing that agent on that substrate at room temperature. The ionic bonds disassociate upon contact with body exudate from wounds to which the wound dressing is applied by ion exchange with ions in the body exudate, thereby to release that agent in an amount proportion to the amount of the exudate in contact with the substrate. This controlled release thus reduces unnecessary exposure of unwounded skin surface to the physiologically-or biologically-active agent.
564950
Miyazaki Masao
Yamazaki Hiroshi
Marcus & Associates
Miyazaki Masao
Yamazaki Hiroshi
LandOfFree
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