Ionizable inhibitors of fatty acid amide hydrolase

Details Ionizable inhibitors of fatty acid amide hydrolase Ionizable inhibitors of fatty acid amide hydrolase

C - Chemistry, Metallurgy

07

C

C07C 271/44 (2006.01) A61K 31/27 (2006.01) A61K 31/41 (2006.01) C07C 271/56 (2006.01) C07D 257/04 (2006.01)

Patent

CA 2654050

Pharmacological inhibition of fatty acid amide hydrolase (FAAH) activity leads to increased levels of fatty acid amides. Esters of alkylcarbamic acids are disclosed that are inhibitors of FAAH activity. Compounds disclosed herein inhibit FAAH activity. Described herein are processes for the preparation of esters of alkylcarbamic acid compounds, compositions that include them, and methods of use thereof.

L'inhibition pharmacologique de l'activité amide d'acide gras hydrolase (FAAH) conduit à des taux accrus d'amides d'acides gras. L'invention concerne des esters d'acides alkylcarbamiques qui sont des inhibiteurs de l'activité FAAH. Les composés selon l'invention inhibent l'activité FAAH. L'invention concerne également des procédés pour la préparation d'esters de composés d'acides alkylcarbamiques, des compositions qui les comprennent et des procédés permettant de les utiliser.

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