Ionization modifier for mass spectrometry

Details Ionization modifier for mass spectrometry Ionization modifier for mass spectrometry

C - Chemistry, Metallurgy

07

D

C07D 207/40 (2006.01) C07K 1/107 (2006.01) G01N 33/483 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2551085

The present invention is concerned with a compounds of the general formula (see formula I) wherein R, R', R", R"', R"", X and n are as defined in the description and the claims and the use of said compound as ionization modifier. The invention further relates to a method for the quantification of a polypeptide or fragments thereof from a source containing said polypeptide in labeled and unlabeled form comprising (a) modifying the isolated polypeptide with a ionization modifier, (b) analyzing the prepared polypeptide or fragments thereof by mass spectrometry, and thereby determining the amount of polypeptide or fragments thereof that was present in the source of polypeptide or fragments thereof.

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