Iontophoresis device for the transcutaneous delivery of an...

A - Human Necessities – 61 – N

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A61N 1/30 (2006.01)

Patent

CA 2211794

A device comprising a reversible negative electrode in contact with a reservoir element containing an electrolyte which contains an active principle such as an anionic oligosaccharide, particularly a pentasaccharide, in at least partially ionised form, a positive electrode alone or in combination with an electrolyte-containing receptacle, and an electrical signal generator connectable to both electrodes. The generator is arranged to apply electrical signals between the electrodes, which signals have an average voltage such that the average current density generated between the electrodes is 0.05-0.25 mA/cm<2>. The amount of active principle in the reservoir element combined with the negative electrode is 0.5-12 mg per cm<2> of the electrode and per mAh of current through 1 cm<2> of the electrode.

Le dispositif comporte une électrode négative réversible, en contact avec un élément réservoir contenant un électrolyte renfermant le principe actif oligosaccharide anionique, notamment pentasaccharide, sous une forme au moins partiellement ionisée, une électrode positive, seule ou associée à un réceptacle contenant un électrolyte, et un générateur de signaux électriques connectable aux deux électrodes. Le générateur est agencé pour appliquer, entre les électrodes, des signaux électriques de tension moyenne telle que la densité du courant moyen généré entre les électrodes est comprise entre 0,05 et 0.25 mA/cm2. La quantité de principe actif présente dans l'élément réservoir associé à l'électrode négative représente 0,5 mg à 12 mg par cm2 d'électrode et par mAh de courant passant par cm2 d'électrode.

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