Iontophoretic drug delivery device having high-efficiency...

A - Human Necessities – 61 – N

Patent

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A61N 1/30 (2006.01)

Patent

CA 2230813

An iontophoresis system includes a transdermal patch (23) for placement against the skin of a patient and a controller (24, 26) electrically connected to the patch (23). The patch (23) includes an anode and cathode electrode, and holds an electrolyte and a medication. The controller includes a DC-DC converter circuit (24) which generates output voltage that is provided to the anode electrode. The controller also includes an adjustable current regulator circuit (26). The current regulator circuit (26) is coupled to the cathode electrode and is adjustable to provide a desired current flow through the electrodes and the skin of the patient. The DC-DC converter circuit (24) is responsive to the voltage drop across the electrodes and adjusts its ouptut voltage in response to this voltage drop and changes in the impedance of the patient's skin.

Système d'iontophorèse constitué d'un timbre transdermique (23) destiné à être placé contre la peau d'un patient et d'un dispositif de commande (24, 26) relié électriquement au timbre (23). Le timbre (23) comporte une anode et une cathode, et supporte un électrolyte et un médicament. Le dispositif de commande comporte un circuit de conversion continu-continu (24) qui produit une tension de sortie amenée à l'anode. Le dispositif de commande comporte également un circuit réglable (26) de régulation de courant. Le circuit de régulation de courant (26) est associé à la cathode et est réglable, de façon à faire passer un flux de courant voulu dans les électrodes et dans la peau du patient. Le circuit de conversion continu-continu (24) réagit à la chute de tension aux bornes des électrodes et règle la tension de sortie en fonction de cette chute de tension et des variations de l'impédance de la peau du patient.

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