Iontophoretic drug delivery system with two-stage delivery...

Details Iontophoretic drug delivery system with two-stage delivery... Iontophoretic drug delivery system with two-stage delivery...

A - Human Necessities

61

N

A61N 1/30 (2006.01) A61N 1/32 (2006.01)

Patent

CA 2079316

A two-stage iontophoretic drug delivery system provides that iontophoretic current is delivered at a first level (I H) for a first prede- termined interval (T2) to rapidly introduce a therapeutic agent into the bloodstream and thereafter reduced to a second lower level (I L) to maintain a desired steady-state ther- apeutic level of the agent. One embodiment provides that the initial interval is main- tained sufficiently long to provide a peak dosage, thereafter which the current is shut off to allow concentration of the agent to subside in the bloodstream, whereupon a maintenance level of iontophoretic current is initiated. Another embodiment provides that the patient may selectively initiate a brief in- terval of increased iontophoretic current le- vel to attain a brief interval of increased do- sage.

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