Iontotherapeutic device and process and iontotherapeutic...

A - Human Necessities – 61 – N

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128/104, 167/205

A61N 1/30 (2006.01)

Patent

CA 1326195

ABSTRACT IONTOTHERAPEUTIC DEVICE AND PROCESS AND IONTOTHERAPEUTIC UNIT DOSE This invention relates to development of an iontothera- peutic device for regulated transdermal systemic administra- tion of ionizable pharmaceutical compounds. It also provides an iontotherapeutic process for trans- dermal administration of ionized pharmaceuticals, particu- larly those which are otherwise transdermally absorbed to a small degree or not at all, such as peptide pharmaceuticals, for example, insulins. The invention also relates to unit dose forms, for example, those in which an ionized pharma- ceutical is dispersed in a hydrophilic polymer. The unit dose is adapted to be assembled as part of the pharma- ceutical reservoir electrode, so that the ionized pharmaceu- tical will be delivered transdermally and then be absorbed systemically when the iontotherapeutic device is in opera- tion. - 65 -

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