Ip-10 based immunological monitoring

Details Ip-10 based immunological monitoring Ip-10 based immunological monitoring

G - Physics

01

N

G01N 33/68 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2662429

The present invention relates to an immunological method and, more particularly, a method for measuring cell-mediated immune reactivity (CMI) in mammals based on the production of IP-10.The invention further discloses an assay and a kit for measuring CMI to an antigen using whole blood or other suitable biological samples. The methods of the present invention are useful in therapeutic and diagnostic protocols for human, livestock and veterinary and wild life applications, thus the invention further relates to a method for diagnosing an infection in a mammal.

Cette invention concerne une méthode immunologique, et plus particulièrement une méthodes permettant de mesurer chez des mammifères une une réactivité immunitaire à médiation cellulaire (Cell-mediated immune reactivity/CMI) basée sur la production de IP-10. L'invention concerne également une analyse et une trousse de mesure de la réactivité à médiation cellulaire CMI à un antigène au moyen de sang entier ou d'autres échantillons biologiques convenables. Les méthodes de la présente invention conviennent pour des protocoles thérapeutiques et diagnostiques applicables à l'homme, au bétail, au gibier et à usage vétérinaire. Ainsi, l'invention porte sur une méthode de diagnostic d'une infection chez un mammifère.

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