Ipratropium formulation for pulmonary inhalation

Details Ipratropium formulation for pulmonary inhalation Ipratropium formulation for pulmonary inhalation

A - Human Necessities

61

K

A61K 31/46 (2006.01) A61K 9/12 (2006.01) A61K 9/14 (2006.01) A61K 9/72 (2006.01) A61P 11/06 (2006.01) A61P 11/08 (2006.01) A61M 11/00 (2006.01) A61M 15/00 (2006.01)

Patent

CA 2441549

Pharmaceutical aerosol formulations are provided comprising substantially nonacicular particles of a bronchodilator selected from the group consisting of ipratropium and pharmacologically acceptable salts, solvates, hydrates, esters and isomers thereof. The described formulations include a propellant selected from the group consisting of a fluorocarbon propellant, a hydrogen- containing fluorocarbon propellant, and mixtures thereof. The formulations are substantially free of both surfactant and solvent. Methods of use and drug delivery devices are also provided.

L'invention concerne des formulations aérosol pharmaceutiques comprenant des particules sensiblement non-aciculaires d'un bronchodilateur choisi dans le groupe renfermant de l'ipratropium et des sels, solvates, hydrates, esters et isomères pharmacologiquement acceptables de celui-ci. Les formulations décrites renferment un propulseur choisi dans le groupe comprenant un propulseur fluorocarbone, un propulseur fluorocarbone contenant de l'hydrogène et des mélanges de ceux-ci. Lesdites formulations sont sensiblement exemptes de tensio-actif et de solvant. L'invention traite également de procédés d'utilisation et de dispositifs d'administration de médicament.

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