C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2473281
Isolated nucleic acid encoding the amino acid sequence of murine IRAK-M; expression vectors comprising nucleic acid encoding IRAK-M and host cells comprising them are disclosed. IRAK-M is induced upon toll-like receptor (TLR) stimulation and negatively regulates TLR signaling. Methods for identifying antagonists and agonists of IRAK-M are described.
La présente invention se rapporte à un acide nucléique isolé codant pour la séquence d'acides aminés de l'IRAK-M murin, à des vecteurs d'expression comprenant ledit acide nucléique codant pour IRAK-M et à des cellules hôtes comprenant ces derniers. IRAK-M est induit lors de la stimulation des récepteurs de type Toll (TLR) et régule négativement la signalisation TLR. L'invention concerne également des procédés d'identification d'antagonistes et d'agonistes d'IRAK-M.
Flavell Richard A.
Kobayashi Koichi
Medzhitov Ruslan M.
Bereskin & Parr
Flavell Richard A.
Kobayashi Koichi
Medzhitov Ruslan M.
Yale University
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