Ire-1alpha inhibitors

Details Ire-1alpha inhibitors Ire-1alpha inhibitors

C - Chemistry, Metallurgy

07

C

C07C 47/54 (2006.01) A61K 31/33 (2006.01) C07C 47/548 (2006.01) C07D 213/24 (2006.01) C07D 215/12 (2006.01) C07D 217/14 (2006.01) C07D 275/03 (2006.01) C07D 295/00 (2006.01) C07D 333/10 (2006.01)

Patent

CA 2690913

Compounds which directly inhibit IRE-1.alpha. activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

L'invention concerne des composés qui inhibent directement l'activité IRE-1a in vitro, des promédicaments et sels pharmaceutiquement acceptables de ceux-ci. De tels composés et promédicaments sont utiles pour traiter des maladies associées à la réponse de protéine non pliée et peuvent être utilisés comme agents simples ou dans des multi-thérapies.

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