C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/02 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 27/02 (2006.01) C12N 15/18 (2006.01)
Patent
CA 2559161
The features of the present invention relate to compounds, compositions and methods useful for modulating the expression of vascular endothelial growth factor (VEGF), such as by the mechanism of RNA interference (RNAi). The compounds and compositions include iRNA agents that can be unmodified or chemically-modified.
La présente invention concerne des composés, des compositions et des méthodes permettant de moduler l'expression du facteur de croissance de l'endothélium vasculaire (VEGF), tel que, par exemple, au moyen du mécanisme d'interference ARN (ARNi). Les composés et les compositions comprennent des agents ARNi qui peuvent être non modifiés ou chimiquement modifiés.
de Fougerolles Antonin
Frank-Kamenetsky Maria
Hadwiger Philipp
Manoharan Muthiah
Rajeev Kallanthottathil G.
Alnylam Pharmaceuticals Inc.
Smart & Biggar
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