C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2417310
The present invention relates to the discovery of markers for neurodegenerative disease. More particularly, it was discovered that forms of IRP-2 protein that are unable to undergo oxidation at critical cysteine residues are diagnostic for neurodegenerative disease including, but not limited to Alzheimer's Disease (AD). Embodiments include nucleic acids that encode mutant IRP-2 proteins and fragments thereof, mutant IRP-2 proteins and fragments thereof, antibodies directed to epitopes present on mutant IRP-2 proteins and fragments thereof, methods of making these nucleic acids and polypeptides, as well as, approaches to diagnose neurodegenerative disease in animals, such as humans at risk of contracting AD or mild cognitive impairment syndrome (MCI). The level or distribution of iron in a human brain, as determined by magnetic resonance imaging (MRI), can be used to diagnose AD and/or MCI.
La présente invention concerne la découverte de marqueurs destinés aux maladies neurodégénératives. Plus spécifiquement, on a découvert que des formes de la protéine IRP-2 qui ne peuvent subir l'oxydation au niveau de résidus de cystéine critiques servent de diagnostic aux maladies neurodégénératives, notamment mais pas uniquement à la maladie d'Alzheimer. Des modes de réalisation ont trait à des acides nucléiques codant des protéines IRP-2 mutantes et des fragments correspondants, lesdites protéines IRP-2 mutantes et lesdits fragments correspondants, des anticorps anti-épitopes présents sur des protéines IRP-2 mutantes et des fragments correspondants, des méthodes d'élaboration de ces acides nucléiques et polypeptides, ainsi que des approches permettant de diagnostiquer une maladie neurodégénérative chez des animaux, y compris des êtres humains présentant un risque de contracter la maladie d'Alzheimer ou le syndrome de déficience cognitive légère. On peut utiliser le niveau ou la distribution du fer dans un cerveau humain par imagerie à résonance magnétique en vue de diagnostiquer la maladie d'Alzheimer et/ou ledit syndrome de déficience cognitive légère.
Anton Lennart
Kang Dae-Kyung
Kelln Wayne J.
Kirsch Wolff M.
Levine Rodney L.
Fetherstonhaugh & Co.
Loma Linda University Medical Center
The Government Of The United States Of America Represented By The Secre Tary Of The Department Of Health And Hu
LandOfFree
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