Irreversible cysteine protease inhibitors containing vinyl...

Details Irreversible cysteine protease inhibitors containing vinyl... Irreversible cysteine protease inhibitors containing vinyl...

C - Chemistry, Metallurgy

07

K

C07K 5/00 (2006.01) A61K 31/27 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) A61K 38/04 (2006.01) C07C 317/28 (2006.01) C07D 295/205 (2006.01) C07D 295/215 (2006.01) C07F 9/6533 (2006.01) C07K 4/00 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/087 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2184098

Irreversible cysteine protease inhibitors based upon an alkene bond being conjugated to an electron withdrawing group are disclosed. The inhibitor structure also provides a targeting peptide which is specific for different cysteine proteases. The method of making the inhibitors, and methods of using the inhibitors to inhibit cysteine proteases and for therapy are disclosed.

L'invention concerne des inhibiteurs irréversibles de cystéine-protéase, fondés sur la conjugaison d'une liaison alcène avec un groupe attracteur d'électrons. La structure de ces inhibiteurs contient aussi un peptide de ciblage, spécifique de différentes cystéine-protéases. L'invention concerne aussi la technique de production de ces inhibiteurs et leurs utilisations pour inhiber les cystéine-protéases et à des fins thérapeutiques.

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