A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/04 (2006.01) A61K 38/10 (2006.01) A61K 39/42 (2006.01) C07H 21/00 (2006.01) C07K 5/00 (2006.01)
Patent
CA 2634589
The inventions provide an isolated antiviral peptide characterized by the amino acid sequence GDEPLENYLDTEYF (SEQ ID:NO 1) and a significant in vitro binding affinity for HIV-1 gp 120 and gp 41 and human CD4 cells. It has postulated anti-retroviral activity in vivo, particularly anti-HIV-1 activity. The inventions further provide pharmaceutical compositions comprising this peptide and methods for preventing, treating, and diagnosing HIV-1 infections and HIV-1 related conditions such as AIDS and ARC with these compositions.
La présente invention concerne un peptide antiviral isolé caractérisé par la séquence d'acides aminés GDEPLENYLDTEYF (SEQ ID:NO 1) et une grande affinité de liaison in vitro pour VIH-1 gp 120 et gp 41 et des cellules CD4 humaines. Il possède une activité antirétrovirale concevable in vivo et en particulier une activité anti VIH-1. Cette invention concerne aussi des compositions pharmaceutiques comprenant ce peptide et des techniques de prévention, de traitement et de diagnostic d'infections par le VIH-1 et d'états liés au VIH-1 tel que le sida et l'Arc avec ces compositions.
Hill & Schumacher
Zhabilov Harry H.
LandOfFree
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