Irritation-reducing ocular ionthophoretic device

A - Human Necessities – 61 – N

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A61N 1/30 (2006.01) A61F 9/00 (2006.01)

Patent

CA 2591267

The invention relates to an ocular ionthophoretic device for supplying active principles comprising an active principle container placeable on an eye, an active principle solution in the container, an active electrode arranged in the container and a negative electrode, wherein the inventive device contains the active principles dissolved in non-saline water, the pH of said solution ranges from 6.5 to approximately 8.5, the active principles have a pKa ranging from 5.5 to approximately 9.5 and are bonded to an adjuvant such as dendrimers, polymers, nanoparticles, microspheres, liposomes or emulsions and have an ionic form whose valence is equal or greater than 1.

L'invention concerne un dispositif de iontophorèse oculaire (1), pour la délivrance de principes actifs, comportant un réservoir (20) de principes actifs apte à venir se positionner sur l'oeil, des principes actifs en solution dans le réservoir, une électrode active(10) disposée dans le réservoir, et une électrode passive, caractérisé en ce qu'il comprend des principes actifs dissous dans de l'eau non saline, en ce que la solution qu'il contient a un pH compris entre 6,5 et 8,5, en ce que les principes actifs ont un pKa compris entre environ 5,5 et environ 9,5 et sont liés à un adjuvant, tel que des dendrimères, des polymères, des nanoparticules, des microsphères, des liposomes ou des émulsions et ont une forme ionique de valence supérieure ou égale à 1.

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