C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2594318
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-2, as well as methods for treating various B cell malignancies, including non- Hodgkin's lymphoma.
La présente invention a trait à des anticorps monoclonaux isolés, notamment des anticorps monoclonaux humains, de liaison spécifique à IRTA-2 avec une affinité élevée. L'invention a également trait à des molécules d'acide nucléique codant pour les anticorps de l'invention, à des vecteurs d'expression, à des cellules hôtes, et à des procédés pour l'expression des anticorps de l'invention. L'invention a trait en outre à des immunoconjugués, des molécules bispécifiques et des compositions pharmaceutiques comportant les anticorps de l'invention. L'invention a trait enfin à des procédés de détection de IRTA-2, ainsi qu'à des procédés pour le traitement de diverses malignités de la cellule B, comprenant le lymphome non Hodgkinien.
Cardarelli Josephine
Graziano Robert
Huang Haichun
King David J.
Srinivasan Mohan
Medarex Inc.
Smart & Biggar
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