A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07H 21/04 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2561276
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-5 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-5, as well as methods for treating various B cell malignancies, including non- Hodgkin's lymphoma.
La présente invention concerne des anticorps monoclonaux isolés, notamment des anticorps monoclonaux humains qui se lient spécifiquement à IRTA-5 avec une forte affinité. Des molécules d'acide nucléique codant les anticorps selon l'invention, des vecteurs d'expression, des cellules hôtes et des méthodes d'expression desdits anticorps sont également présentés ainsi que des immunoconjugués, des molécules bispécifiques et des compositions pharmaceutiques comprenant lesdits anticorps. Cette invention concerne également des méthodes de détection de IRTA-5 ainsi que des méthodes de traitement de diverses malignités de cellules B, y compris le lymphome non Hodgkinien.
Cardarelli Josephine M.
Cutter Beth
Graziano Robert
Kempe Thomas D.
Srinivasan Mohan
Medarex Inc.
Smart & Biggar
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