C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/404 (2006.01) A61K 51/00 (2006.01) A61P 25/28 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2735970
The present invention provides isatin 5-sulfonamide derivatives, pharmaceutical compositions comprising said derivatives, their use as molecular imaging agents, their use for the diagnosis or treatment of diseases or disorders associated with dysregulation of apoptosis, methods for synthesizing said derivatives, methods for the molecular imaging of caspase activity and apoptosis, and methods of assessing the therapeutic effect of a test substance on caspase activity.
La présente invention concerne des dérivés 5-sulfonamide disatine, des compositions pharmaceutiques comprenant lesdits dérivés, leur utilisation en tant quagents dimagerie moléculaire, leur utilisation pour le diagnostic ou le traitement de maladies ou troubles associés à la dérégulation de lapoptose, des procédés pour synthétiser lesdits dérivés, des procédés pour limagerie moléculaire de lactivité caspase et lapoptose, et des procédés dévaluation de leffet thérapeutique dune substance dessai sur lactivité caspase.
Aboagye Eric Ofori
Arstad Erik
Glaser Matthias Eberhard
Nguyen Quang-De
Smith Graham
Hammersmith Imanet Limited
Imperial Innovations Limited
Sim & Mcburney
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