C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/00 (2006.01) A61K 31/395 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 209/32 (2006.01) C07D 209/34 (2006.01) C07D 209/38 (2006.01) C07D 211/18 (2006.01) C07D 243/08 (2006.01) C07D 295/067 (2006.01) C07D 295/096 (2006.01) C07D 401/00 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 491/10 (2006.01) C07D 491/113 (2006.01)
Patent
CA 2124826
2124826 9312085 PCTABS00022 The present invention relates to compounds having general formula (1), wherein: X represents one or more substituents independently selected from hydrogen, lower alkyl, aryl, aryloxy, CN, lower alkoxy, halogen, hydroxy, nitro, trifluoromethyl, alkylsulphonamido, NHCOR where R is lower alkyl or aryl, NR1R2 where R1 and R2 are independently hydrogen or lower alkyl or together form a ring, CO2R where R is lower alkyl, or cycloalkyl, cycloalkenyl or bicycloalkyl either optionally further substituted by lower alkyl; Y is CO or CR3R4 where R3 and R4 are independently hydrogen, lower alkyl, lower alkoxy or together form a cyclic acetal; Z is N or CH; stereo and optical isomers and racemates thereof where such isomers exist, as well as pharmaceutically acceptable acid addition salts thereof and solvates thereof; having therapeutic activity, intermediates for their preparation, processes for their preparation, pharmaceutical formulations containing said compounds and medicinal use of said compounds and similar known compounds.
Boar Bernard Robin
Cross Alan John
Astra Aktiebolag
Fetherstonhaugh & Co.
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