Isatineoxime derivatives, their preparation and use

Details Isatineoxime derivatives, their preparation and use Isatineoxime derivatives, their preparation and use

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) C07C 205/45 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2076948

A compound having the formula (See formula I) wherein R4 and R5 independently are hydrogen, halogen, CF3, CN, NO2 or SO2NR1R2 wherein R1 is hydrogen or straight, C1-6-alkyl which may be branched or cyclic, R2 is hydrogen or straight, C1-6-alkyl which may be branched or cyclic, or wherein R1 and R2 together represent -(CH2)n;-A-(CH2)m-. wherein A is O, S, CH2 or NR I, wherein R I is H, C1-6-alkyl which may be straight, branched or cyclic, n is 0, 1, 2, 3, 4, 5 and m is 0, 1, 2, 3, 4, 5; Q is NOH, O; Z = O, S, N-R II, (See formulas) wherein R II, R III, R IV and R V independently are hydrogen, benzyl, C1-6-aryl, C1-6- alkoxy which may be branched or cyclic, or C1-6-alkyl which may be branched or cyclic; X is -(CH2)o- wherein a is 0, 1, 2, or 3; Y is -(CH2)p- wherein p is 0, 1, 2 or 3; .alpha. and .beta. indicate attachment points, and a method of treating disorders of a mammal, including a human, responsive to the blockade of glutamic and aspartic acid receptors, with the same.

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