A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01)
Patent
CA 2491457
The invention relates to a composition comprising a mixture of at least two iscom complexes each complex comprising essentially one saponin fraction from Quillaja Saponaria Molina. The complexes may be iscom complexes or iscom matrix complexes. The invention also pertains to the use of such a mixture for the prepa-ration of an immunomodulating pharmaceutical, and adjuvant, formulations for immunsation e.g. for production of monoclonal antibodies and a vaccine. Kits of parts comprising at least two parts, wherein each part comprises one iscom complex or one iscom matrix complex according to the invention are also embraced.
L'invention se rapporte à une composition comportant un mélange d'au moins deux complexes d'iscom comprenant chacun principalement une fraction de saponine issue de <i>Quillaja Saponaria Molina</i>. Ces complexes peuvent être des complexes d'iscom ou des complexes de matrices d'iscom. L'invention se rapporte également à l'utilisation d'un tel mélange pour la préparation de formulations pharmaceutiques immunomodulatrices, utilisées en tant qu'additifs pour l'immunisation, par exemple pour la production d'anticorps monoclonaux et d'un vaccin. L'invention se rapporte également à des kits multiples comportant au moins deux parties, chaque partie comprenant un complexe d'iscom ou un complexe de matrice d'iscom tel que celui décrit ci-dessus.
Loevgren Bengtsson Karin
Morein Bror
Fetherstonhaugh & Co.
Isconova Ab
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