Isethionate salt of a selective cdk4 inhibitor

Details Isethionate salt of a selective cdk4 inhibitor Isethionate salt of a selective cdk4 inhibitor

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2532049

Disclosed are polymorphs of the isethionate salt of 6-acetyl-8-cyclopentyl-5- methyl-2~(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, which is a selective cyclin-dependent kinase 4 (CDK4) inhibitor useful for treating inflammation and cell proliferative diseases such as cancer and restenosis.

L'invention concerne des polymorphes du sel d'iséthionate de 6-acétyl-8-cyclopentyl-5-méthyl-2-(5-pipérazin-1-yl-pyridin-2-ylamino)-8<I>H</I>-pyrido[2,3-d]pyrimidin-7-one, qui est un inhibiteur sélectif de la kinase 4 dépendante des cyclines, utile pour traiter l'inflammation et les maladies proliférantes cellulaires comme le cancer et la resténose.

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