Isochromane derivatives

Details Isochromane derivatives Isochromane derivatives

C - Chemistry, Metallurgy

07

D

C07D 405/02 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07D 311/76 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2042861

Abstract The invention concerns an isochromane derivative having the general formula I Image I in which R1 is one to four substituents independently selected from hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, or CF3, or as two adjacent substituents together a methylenedioxy group; R2 is one to four substituents independently selected from hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, or CF3, or as two adjacent substituents together a methylenedioxy group; R3 is one to four substituents independently selected from hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, or CF3, or as two adjacent substituents together a methylenedioxy group: R4 is selected from hydrogen or alkyl (1-4 C); A is a bond or an alkylene or alkylidene group with 1-6 carbon atoms; B is an alkylene or alkylidene group with 1-6 carbon atoms when Y is a bond, or B is an alkylene group with 2-6 carbon atoms when Y is a group selected from 0, S, or NR5; X is CH or N; and R5 is selected from hydrogen or alkyl (1-4 C); or a pharmaceutically acceptable salt thereof. The compounds can be used in the treatment of angina pectoris, cardiac dysrhytmias, cardiomyopathies, stroke, sudden death, and myocardial infarction.

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