Isochromane derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 311/76 (2006.01) A61K 31/35 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2039009

Abstract An isochromane derivative having the general formula I Image I in which each of R1, R2, and R3 is one to four substituents independently selected from hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, or CF3, or represents a methylenedioxy group; R4 is selected from hydrogen or alkyl (1-4 C); Alk is an alkylene group with 1-4 carbon atoms; Alk' is an alkylene group with 2-4 carbon atoms, when R5 is selected from hydrogen or alkyl (1-4 C) and X is O or S; or Alk' is an alkylene group with 1-4 carbon atoms or a bond, when R5 is an alkyl (1-4 C) group and X is CH2 or a bond; or a pharmaceutically acceptable salt thereof.

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