Isocoformycin and a process for the production thereof

Details Isocoformycin and a process for the production thereof Isocoformycin and a process for the production thereof

C - Chemistry, Metallurgy

07

H

260/229.8

C07H 19/04 (2006.01)

Patent

CA 1090792

ISOCOFORMYCIN AND A PROCESS FOR THE PRODUCTION THEREOF ABSTRACT OF THE DISCLOSURE A novel, unique nucleoside, 3-.beta.-D-ribofuranosyl- 3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-7-ol, named isocoformycin, of the formula Image is provided by ring expansion of derivatives of 9-.beta.-D- ribofuranosyl-6-hydroxymethyl-1,6-dihydropurine. Isoco- formycin markedly inhibits deaminating enzymes which in- activate formycin and adenine arabinoside (also known as ara-A and Vidarabine). Formycin and adenine arabinoside are used as antiviral and antitumor agents in mammals and birds and isocoformycin is advantageous to prolong the activity and effect of formycin and adenine arabinoside.

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